Pool cabana during the day is key. Make sure to book one with a tv to watch sports. You can spend the day drinking, swimming, relaxing, etc., and have it as a convenient meeting place if folks want to go and come throughout the day. For Sunday, I would maximize football watching by reserving space (now) at a sportsbar/restaurant in the hotel (I can't comment on specifics without knowing where you are staying), or stake out enough space (early) in the sportsbook for your group. The first football weekend will be jammed, so I would be prepared to grab seats/couches in the sportsbook well before the first games (which will be very early Vegas time).
Focus your evenings around great restaurants (way too many to recommend) - rather than clubs. Book private rooms at the restaurants since many simply require a minimum you would likely meet in any event. Post dinner, folks can branch off as some will probably want to gamble, some club, some nakedness.
Lots of great outdoors stuff to do too, which others have touched upon if you want to mix it up.
