This was discussed about 6 years ago - the idea was known as "Game 39" or "the 39th Step". It proved monumentally unpopular with fans and was forced to be dropped because of the sheer scale of the negative backlash. The problem is that, unlike US sports, where the idea of playing an uneven number of games against different teams home/away due to your conference system is fairly common, in the UK all leagues are organised under the strict understanding that every team must play the same number of games home and away against each team. Playing a game in a foreign country would basically be adding an extra match against one opponent to everyone's schedule, and the only reason they are really proposing to do it is to earn even more money for themselves.
What if, say, Chelsea and Liverpool were tied on points after 38 games at the end of the season and they both came to the US to play a 39th game, but Chelsea got Burnley and Liverpool got Man United? There would be legal challenges and complaints to UEFA and the CAF flying in left, right and centre, it would potentially destroy the league.
On top of this there's the problem that, in a period where football is coming under fire for alienating its home fans by driving prices through the roof, now you're talking about taking games away to places where 99% of the fans can't afford to travel to. It's really driving a wedge between the sport and the fans.
I appreciate you guys all live over the other side of the Atlantic and you're probably really hoping to see some top teams playing meaningful games in a place where you can actually get to watch it live, but I have to be completely and brutally honest about my feelings on this: if this were to ever happen, it would shatter my love for the sport to the point where I'm not sure it could bring myself to remain interested in the league.