Iraola probably starts as soon as the visa clears. same as Lampard. If Pirlo actually signs, ditto. But Angelino probably will need time to adjust. Calle will need some more time to get full max fit. In the meantime, Brovsky/Wingert will mostly likely start at LB until Angelino is proven or at least match fit. If it's Poku or AJ vs. Calle, Poku or AJ get the spot until Calle can prove he's healthy.
Other than that I agree with everyone else, Villa alone at the top isn't the best plan, since he seems to need a partner.
I think part of the reason we need AJ as a defender to protect the back line is because AJ as a distributor gives the ball away a lot. replace AJ and another one of our careless midfield players with Pirlo and Lampard and we should see an improvement in our ability to transition the ball from defense to offense through the midfield. We should also see a reduction in poorly timed give always that result in our FB getting completely caught out of position. If we can improve those areas I think we can go with Calle or Poku over Jacobson.