After crushing losses like that in other leagues, many times teams will do wholesale changes to force a point. We can't be so drastic because our bench isn't stocked with starters, but there has to be a shakeup of some sort. Some of these players need to take a step back and realize doing the same stuff over and over in losses is not helping their case for minutes and hurting the team. I'd sit: Shelton, Saunders, Hernandez, RJ, TMac.
Harrison  -   Villa  -  Mendoza
                Pirlo  - Mix
                    Bravo
Mata  -  White  -  Brillant  -  Iraola
                    Lurch
Or play Villa up front with Mendoza and drop Harrison deeper to a left midfield role to relieve some pressure in the midfield - it's all semantics anyway.
TMac as a spark off the bench. Are the increase in minutes catching up with him?
If it turns out Bravo is suspended for yellows, then Medhi takes his spot.